Since the skin around the eyes is very thin and also very sensitive and delicate, it shows the earliest signs of ageing. Administering this does not require a skin compatibility test. SPF is another important factor that one must watch out for, it is necessary to use a cream with the SPF Top Collagen Disease @ collagendisease.the-zyprexa-lawyer.tech value anywhere between 15 and 30. They are rich in vitamin C, thus helping to strengthen collagen formation, and reduce the effects of ageing. Their functioning, whether through injections or topical application serum or creams, depends upon factors such as the type of wrinkle filler you have chosen, how deep they are, and how elastic and flexible the skin is.